The Navy Operational Support Center (NOSC) New Orleans was formed in October 2004 with the merger of Navy Air Reserve New Orleans and Naval Reserve Center New Orleans. Originally located in several buildings around the base, the main elements of the command have resided in the Frank J. Uddo Armed Forces Reserve Center (Building 492) since January 2005.

The command's primary mission is to provide strategic depth and deliver operational capabilities to the Navy and Marine Corps team and Joint forces from peace to war. The NOSC ensures Navy Reservists maintain a high state of mobilization readiness for rapid deployment if called upon while also providing routine support contributions to Fleet missions around the globe. The command staff includes two officers, two chief petty officers, 15 enlisted and four civilians. They support more than 350 selective Reservists in 18 Reserve units.

NOSC New Orleans also hosts the financial comptroller office for local squadrons and FRC Detachment New Orleans. Additionally, NOSC New Orleans serves as a Tier 1 EKMS program manager, generating and distributing electronic key material for COMSEC equipment at area tenant commands.